One of the active phytocannabinoids isolated from the cannabis plant is cannabidiol and CBD. It is used for many health benefits, reducing anxiety, depression, managing chronic pain, inflammation and giving neuroprotective effects. Know more about how CBD is metabolized in the body.

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How CBD is metabolized?

The metabolism depends on the route of administration, the count of drugs it enters systemic circulation passes metabolism at first. The methods of taking CBD


It is the most common method of consuming CBD is oral. There are different oral CBD products like pills, capsules and edibles. Talking about ingestion, CBD gets absorbed by the digestive system, then from the stomach it enters the liver through the hepatic portal system. In the liver metabolism forms into metabolites.

The remainder of the CBD goes into the bloodstream and gets distributed into the target tissue. The half-life of CBD after oral administration was 2-5 days showing that their effects may not last long.


Through vaporization or smoking CBD is inhaled. It is heated in a manner so that the vapor can be inhaled and the CBD is absorbed in the lungs. The molecules of CBD will bypass first-pass metabolism and are transferred to the bloodstream from the lungs. The CBD bioavailability in smoking is estimated to be 31% and onset action is rapid.


This method of administering CBD is the sublingual route, where the drug is placed under your tongue for 60 seconds and swallowed. It enters the bloodstream by the tiny blood vessels under the tongue.  This method completely bypasses the digestive system and first metabolism and increases bioavailability.

Transdermal and topical patches:

It is involved with the application of CBD with skin ointment. The gastrointestinal administration is avoided and first-pass metabolism. It can come in contact with receptors on the skin a get a local effect. It won’t penetrate deeper skin areas. The transdermal patches on the skin may release CBD penetrates the skin layer and reaches the bloodstream.

Phase 1 in metabolism has an oxidation reaction of CBD. The abundant metabolism was hydroxylated 7-COOH derivatives of CBD and minor transformation was do done with 7-OH-CBD, 6-OH-CBD.

Phase 2 in metabolism involves addition of glucuronic acid to the metabolites. The conjugates formed are later eliminated from the body.


Unchanged CBD and conjugated metabolites are eliminated through feces and urine. The biliary system is the main excretory pathway. Oral CBD study showed that CBD elimination was multiphasic

In the last few years, CBDRevo gjorde en undersøkelse widely for its role in treating different conditions like chronic pain, anxiety, insomnia and depression. It is important to understand the metabolism of CBD, different metabolisms and its influence on physiological function.